Biosynthesis of rosamicin.
نویسندگان
چکیده
منابع مشابه
CYTOCHROME P450 RosC & RosD IN ROSAMICIN BIOSYNTHESIS
Title 1 Function of cytochrome P450 enzymes RosC and RosD in the 2 biosynthesis of rosamicin macrolide antibiotic produced by 3 Micromonospora rosaria 4 5 Running Title 6 CYTOCHROME P450 RosC & RosD IN ROSAMICIN BIOSYNTHESIS 7 8 Yohei Iizaka, Noriko Higashi, Masanari Ishida, Reina Oiwa, Yumi Ichikawa, 9 Moeka Takeda, Yojiro Anzai*, and Fumio Kato 10 11 Faculty of Pharmaceutical Sciences, Toho U...
متن کاملFunction of cytochrome P450 enzymes RosC and RosD in the biosynthesis of rosamicin macrolide antibiotic produced by Micromonospora rosaria.
The cytochrome P450 enzyme-encoding genes rosC and rosD were cloned from the rosamicin biosynthetic gene cluster of Micromonospora rosaria IFO13697. The functions of RosC and RosD were demonstrated by gene disruption and complementation with M. rosaria and bioconversion of rosamicin biosynthetic intermediates with Escherichia coli expressing RosC and RosD. It is proposed that M. rosaria IFO1369...
متن کاملA new Micromonospora-produced macrolide antibiotic, rosamicin.
A new antibiotic, rosamicin, classified as a macrolide, has been isolated from the fermentation broth of a new species of Micromonospora, M. rosaria. The antibiotic is separated from the broth by a solvent extraction procedure and purified by column chromatography. Chromatographic studies indicate that rosamicin is different from all related macrolides and is a novel antibiotic. It has broad-sp...
متن کاملRosamicin: evaluation in vitro and comparison with erythromycin and lincomycin.
Rosamicin is a new macrolide antibiotic produced by Micromonospora rosaria. It shares certain chemical and biological characteristics with erythromycin. Activity against gram-positive strains was assayed by broth dilution and compared to that of erythromycin and lincomycin. Rosamicin was bacteriostatic and inhibited most strains of Staphylococcus aureus, Staphylococcus epidermidis, enterococci,...
متن کاملRosamicin, a macrolide with in vitro activity against Ureaplasma urealyticum.
A new macrolide antibiotic, rosamicin, was shown to have much greater activity in vitro against ureaplasmas isolated from humans than erythromycin or the tetracyclines tested. A marked ureaplasmacidal effect was also shown.
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1976
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.29.976